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four different types of interactions TF → gene, TF → miRNA, miRNA →.
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Pro-inflammatory cytokines, such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interferon-γ (IFN-γ), have been shown to up-regulate microbicidal activity of neutrophils and/or monocytes/macrophages. All four of these cytokines, which are available in recombinant human form, have been proposed and considered as adjunctive immunomodulatory agents to treat serious or refractory infections in humans.[41, 42] Currently, the precise cellular and molecular mechanisms responsible for these effects are not completely understood but may potentially include up-regulation of molecules involved in pathogen recognition, such as TLRs. Indeed, recent studies demonstrated that pretreatment of neutrophils with GM-CSF modulates TLR expression and cytokine responses to several TLR ligands.[37, 38].
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In this retrospective, observational investigation, we studied consecutive adult emergency department intubations at an urban, academic medical center during the calendar year 2013. Cases were identified from the electronic medical record and analyzed using standard video review methodology. We compared first-attempt success rates when standard geometry Macintosh VL was used, stratified by whether the screen was viewed or not.. stimulates Hsp70 expression and Hsp70 complements Hsp90 chaperone. contribute to inter-individual and ethnic variability in the susceptibility. arising in the transgenic adenocarcinoma of the mouse prostate
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Premature labor can increase risk of intraventricular hemorrhage in neonates; intraventricular hemorrhage may result in neurodevelopmental disability (eg, cerebral palsy)..